Techniques

Our MRI Toolbox

CORE GIfMI has experience with multiple techniques, from structural scanning to quantitative mapping and spectroscopy. The techniques listed below are available for in-vivo and ex-vivo imaging of healthy human volunteers, patients in the context of clinical research, animals, as well as phantom experiments.

Contact our MR Physicist

CORE GIfMI actively maintains a full library of optimized sequences, including:

  • T1-weighted imaging
  • T2-weighted imaging
  • T2*-weighted imaging
  • Fluid Attenuated Inversion Recovery (FLAIR)
  • Proton density-weighted imaging
  • 3D imaging: VIBE, SPACE, MP-RAGE, GRASP-VIBE, etc.
  • and more

CORE GIfMI has extensive expertise in research using functional mapping techniques. Combined with the psychophyisological lab, these techniques enable wide-ranging opportunities for fMRI research:

  • BOLD fMRI
  • Simultaneous multi-slice (SMS) fMRI (Siemens and CMRR sequences)
  • Task-based fMRI
  • Resting-state fMRI
  • and more

The techniques are grouped into the following categories, according to the categorization described in Seiberlich, Nicole, Gulani, Vikas: Quantitative Magnetic Resonance Imaging. Academic Press; 2020. [Advances in Magnetic Resonance Technology and Applications, vol. 1][1].

Relaxometry

  • T1 mapping: Inversion recovery, Look-Locker, Variable Flip Angle, MP2RAGE
  • T2 mapping: Multi-echo, Multi-spin echo, T2-prepared
  • T2* mapping: Multi-echo, Multi-gradient echo

Perfusion and permeability

  • Arterial Spin Labelling (ASL)
  • Dynamic contrast-enhanced MRI (DCE) [not usable for healthy volunteers]
  • Dynamic susceptibility contrast MRI (DSC) [not usable for healthy volunteers]
  • Intravoxel incoherent motion (IVIM)

Diffusion

  • ADC mapping
  • Diffusion tensor imaging (DTI)
  • High-angular resolution diffusion imaging (HARDI)
  • Diffusion kurtosis imaging (DKI)
  • Neurite orientation dispersion and density imaging (NODDI)
  • Intravoxel incoherent motion (IVIM)
  • Segmented diffusion-weighted imaging (RESOLVE)

Spectroscopy

  • Single-voxel
  • Multi-voxel

Fat and Iron quantification

  • Proton Density Fat Fraction (PDFF)
  • R2/T2 mapping

Quantification of Other MRI-Accessible Tissue Properties

  • 2D Flow (phase contrast)
  • 4D Flow
  • Quantitative susceptibility mapping (QSM)
  • Magnetic resonance elastography (MRE)
  • Magnetization transfer imaging (MT)
  • Chemical Exchange mapping (CEST)
  • MR Thermometry

CORE GIfMI has on-scanner and offline access to multiple tools for sequence programming, image reconstruction and post-processing tools:

  • Siemens C2P
    The MRI pulse sequence sharing platform of Siemens Healthineers
  • Siemens IDEA
    The sequence programming platform of Siemens Healthineers
  • Siemens ICE
    The image reconstruction platform of Siemens Healthineers
  • Siemens OpenRecon
    The inline image reconstruction platform of Siemens Healthineers
  • Pulseq
    An open-source tool to design and share customizable MRI pulse sequences compatible with various scanners
  • gammaSTAR
    A framework designed to create and deploy standardized MRI protocols across multiple scanner brands

CORE GIfMI has access to multiple platforms for computing and data post-processing.

  • HPC-UGent
    The high performance computing infrastructure with lots of tools preinstalled and a huge computing power.
  • Neurodesk:
    An environment running on the HPC for neuroimaging data analysis, see also our resources page.
  • Siemens syngo.sia Frontier
    The Siemens Healthineers research platform

CORE GIfMI has specialized sequences and phantoms for MRI quality control, including:

  • Standard Siemens phantoms
  • ACR-NEMA Large and Small phantom
  • fBIRN compatible phantom (FUNSTAR - Functional Stability Reference)
  • ASL phantom (QASPER - Quantitative Arterial Spin Labelling Perfusion Reference)
  • We provide advice on building custom phantoms.